About the Library of Brain Glycans (LBG)

The Library of Brain Glycans (LBG) is a freely accessible, curated database designed to advance research in neuroglycobiology. Brain glycans exhibit unique structural diversity, yet their identification and characterization remain challenging due to limited resources and specialized tools. LBG addresses this need by systematically cataloging biological data on glycans detected in brain tissue.

The LBG was created to bridge this gap by providing a comprehensive, searchable resource for glycans identified in brain tissue. It integrates data from multiple experimental techniques, including mass spectrometry and liquid chromatography, offering detailed insights into glycan composition, structure, as well as data regarding glycan expression in situ to provide a biological context. Researchers can explore glycans by species, brain region, developmental stage, and other physiological variables, making it easier to identify and compare glycan structures across different studies.

Each entry includes:

Monosaccharide composition with graphical representation and diagnostic fragments
Normalised hydrophilic interaction ultra-performance liquid chromatography (HILIC UPLC) glucose unit (GU) values and glycan mass data
Comparison of isomers and unique glycan identifiers
Detailed metadata on biological samples, including species, age, and brain region

At launch, LBG contains over 300 N-linked glycans, with plans for expansion to include additional glycan types. As a living library, it will continue to grow, incorporating new datasets and evolving alongside discoveries in the field.

By making brain glycan data easily accessible and searchable, LBG supports researchers in identifying and characterizing glycans from complex biological samples—ultimately advancing our understanding of brain glycosylation.

Start your search of the Library of Brain Glycans: https://lbg.human-glycome.org/